With the invention of the printing press the knowledge was made easier to spread which led to greater education and greater social mobility. This also made the Bible accessible to more people. People were looking for more personalized approach to their spiritual needs. It was Martin Luther who made openly challenged the teachings of the Catholic Church by posting his famous thesis against the selling of indulgences. After they branded him a heretic he denied the idea that the Church is a mediator between God and man.
Settlers wanted land, chance to start a new life. Mountain men travelled west for adventure. Middionaries travelled to convert native American to shristianity.
The answer is "t<span>he confederation among the states was too strong and too centralized" as this statement is not true so it can not be a disadvantage. </span>
Because the ships carrying the plague didn’t go their also they were a bit more clean