The Populist platform that Mary E. Lease was known for was called the People's Party.
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The activities that most demonstrated Americans' belief in Manifest Destiny occurred during the 19th century, while thousands of settlers moved west and displaced thousands of natives.
The Louisiana Purchase, which was actually made by Jefferson himself, was a shift in his general principles because it required great power on behalf of the federal government, which Jefferson himself didn't like. The same goes for the Monroe Doctrine.
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Slavery made some colonies more likely to exploit large numbers of enslaved africans