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Explanation:
In the 21st century, biotechnology has developed rapidly, and the era of great health has arrived. Cell therapy has opened up new ideas for the treatment of refractory diseases in human beings and has broad application prospects. Cell biology, molecular biology, and modern immunology are the three leading modern biological sciences. Cell therapy utilizes the characteristics of certain cells with specific functions. After bioengineering or in vitro amplification and special culture treatment, these cells have therapeutic effects such as enhancing immunity, killing pathogens and tumor cells, and promoting tissue regeneration, so as to achieve the purpose of treating diseases. Techniques such as cell culture proliferation and differentiation are among the most commonly used methods in cell biology research. Since the basic laws of cell behavior are the same in vitro culture and in vivo, many studies can be performed in vitro. More importantly, people can selectively and purposefully control the environment in which cells grow, so they can study the biological behavior of cells under certain special conditions.
Assay Development Service
Genetic/epigenetic analysis service
Epigenetics refers to the regulation of epigenetic gene expression by epigenetic changes (DNA methylation, histone modifications, and non-coding RNAs such as miRNAs) that are independent of genetic sequence changes and can be genetically apparent. DNA methylation, histone modifications, and miRNAs are a reflection of changes in environmental stimuli that interact to regulate gene expression and control cellular phenotype. Massively parallel sequencing technology lays the foundation for the construction of epigenomics. Creative Biolabs provides key sequencing-based methods used in the analysis of epigenomes, including bisulfite sequencing, chromatin immunoprecipitation sequencing, 3D chromatin capture, as well as the determination of open chromatin.
In vitro assay development service
In vitro or phenotypic assays are defined as those that model some aspect of disease biology in cells or tissues derived from an experimental species or humans, which have important clinical implications for disease progression and treatment. In vitro assays have the following benefits: obtaining direct knowledge related to the potential new disease background; multiple compounds with different modes of action can be tested, and depending on the throughput of the assay, within a certain range; it provides data support for more complex phenotypes or subsequent assessments or in vivo trials. The examples given in the various disease areas use a wide range of cell-based assay types, typically in 96-well formats, which differ markedly in their outcome when compared to, for example, biochemical or in vivo assays.
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In vivo assay development service
The experimental animals themselves are studied for their breeding, biological characteristics and information, new varieties cultivation and disease diagnosis, treatment, and prevention to achieve people's purposes. Taking animals as a model, some experiments are carried out in vivo to study the reactions, manifestations and developmental rules of animals, and lay the foundation for solving complex diseases of human beings. The services of in vivo assay include assessing the phenotypic characteristics of transgenic lines, functional MRI services for awakening animals to visualize neural networks, and assessing transporter activity and building animal models, etc.