I am doing it for points because it just so happened you asked me not to. :)
Spain and Portugal controlled land in Latin and South America. Spain controlled what is now Mexico, New Mexico and Texas. It also controlled countries part of South America such as Argentina,Colombia and Venezuela. Portugal controlled Brazil. France controlled parts of the United States(Louisiana purchase land). It also had control of Canada.
Culture, and economic power. The north was industrial, and the south was agricultural. As for culture, the north was more British, and the South was more French and Spanish.
Answer:
Mesoamericans did not have resistance to unfamiliar diseases introduced by the Europeans.
Mass deaths contributed to the collapse of culture.
