The answer is a) human rights issues
When you enumerate you need to put comas between all the items except the ones which are connected by "and" : as A is not correct as it does not have comas, and B is incorrect as it has comas where "and" is.
now, in a way both C and D are correct, but C is the usual accepted version, and D is an example of "Oxford coma" (where the coma is optional, to remain on the safe side, choose C).
The chamber in which the narrator is positioned, is used to signify the loneliness of the man, and the sorrow he feels for the loss of Lenore.<span> The room is richly furnished, and reminds the narrator of his lost love, which helps to create an effect of beauty in the poem.</span>
4. I was late because there was a lot of traffic