Question

1) A mutation occurred in DNA of a globular enzyme. If the lysine amino acids were found within the active site of the enzyme, describe the effect this change is likely to have on enzymatic function.
2) If a mutation in the DNA of a globular enzyme changed all of the lysine amino acids to aspartic acid, predict how the relative position of the amino acid in the tertiary structure of the protein would be affected when the protein is placed in an aqueous solution. Justify your prediction by providing evidence that supports your claim.

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Answer 1

The lysine amino acid will provide a positive charge to the active site. If this mutation changed all of the lysine amino acids to aspartic acid, it will produce an enzyme having a negative charge.

Mutations and amino acids

A mutation is any alteration in the nucleotide (DNA) sequence of the genome of an organism.

A mutation that alters the active site of an enzyme will invariably affect its catalytic activity.

A mutation that involves a change in lysine (positive) to aspartic acid (negative) will produce a protein having a net negative charge.

Learn more about mutations here:

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