Two of these changes were the new capital at Byzantium and the new Christian character of the empire (Constantine legalized Christianity and eventually converted himself). These changes eventually created a distinct culture which would characterize the Byzantine Empire after the fall of the Western Roman Empire in 476.
A rich politician/Sponsor or the Emperor
They can change your point of view to where you won’t listen to anyone else and it can hurt you in the long run by just trying to do good.
