I am sort of puzzled on this particular question; however, I think I solved it. Okay, so the text starts with explaining the benefits of coffee, then it proceeds to explain the negative affects of consuming coffee. Transition words like <em>on the other hand</em> are commonly used when contrasting ideas. Hence, I believe the correct answer is c. contrast.
Ok I’m checking right now
<span>B. It is significant to people from many cultures.</span>