The beneficial uses of bacterial toxins in medicine are more and more used lately. For example, Botulinum toxin is a toxic protein produced by the bacterium Clostridium botulinum which has paralytic effects (injection of this toxin into muscle relax specific muscles). Botulinum toxin accomplishes his effects on the neuromuscular junction where he prevents the release of the neurotransmitter acetylcholine (Ach). Utilization of this toxin is in the treatment of various muscle spasms. It is also used in the treatment of migraines. Diphtheria toxin is also one of the toxins used for medical purposes for the treatment of cutaneous and non-Hodgkin T-cell lymphomas. <span>Some bacterial toxins can be used in the treatment of tumours. For example, immunotoxin, which is protein made by fusion of modified antibody and toxin.The antibody binds to an antigen on the target cell, the toxin then enters via endocytosis and kills the cell. Commonly used bacterial toxins in immunotoxins are Diphtheria toxin and the Pseudomonas exotoxin.</span>
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Every recognized species on earth (at least in theory) is given a two-part scientific name. This system is called "binomial nomenclature." These names are important because they allow people throughout the world to communicate unambiguously about animal species.
Answer:
sounds hard have a good day
Explanation:
Answer and Explanation:
The Huntington disease is caused by a mutation in the gene that codifies for the Huntingtin protein (Htt). The mutation produces an altered form of the protein leading to the neuron´s death in certain areas of the brain.
The Huntington disease characterizes for being,
- Hereditary, passing from generation to generation. To express the disease, a person must have been born with an altered gene.
- Autosomal, affecting men and women equally, because the mutated gene is located on an autosomal chromosome.
- Dominant, which means that by getting only one copy of the altered gene coming from any of the parents, the receiving person will express the disease. The mutation in the gene dominates over the normal gene copy.
- Expressed by heterozygosis. Most people affected by the disease are heterozygous, with a normal copy and a mutated copy.
There are just a few cases all around the world (3% approximately) in which the disease is expressed with no family history. The progenitors are not affected by the mutation. These cases are very rare and are called <u>"de-novo" mutations.</u> A new mutation is spontaneously produced and it is not inherited from any of the parentals. It consists of an increase in the number of CAG repetitions. In a normal person, the number of CAG repetitions is less than 35. When there are 40 or more repetitions it occurs the disease. But when there are between 35 and 39 repetitions, the penetrance of the disease is incomplete. This is a "gray zone". Those alleles that fall in the gray zone are unstable and might produce the HD. Individuals with these unstable alleles have a tendency to increase the number of repetitions from generation to generation until the number reaches 40 repetitions and the person expresses the disease. This <u>usually occurs in the paternal germinal line</u>, as it is particularly unstable in sperm and probably meiosis greatly affects their instability, causing an increase in the number of CAG repeats.
