The influence of the fast-acting inhibitor of t-PA on clot lysability by endogenous or exogenous t-PA was investigated by immersing clots prepared from normal or inhibitor-rich plasma (endogenous inhibitor) in normal or inhibitor-rich plasma (exogenous inhibitor). Exogenous t-PA inhibitor efficiently neutralizes clot lysis by both exogenous and endogenous t-PA. Endogenous t-PA inhibitor, however, efficiently neuralizes endogenous t-PA but has little influence on clot lysis by exogenous t-PA. These findings indicate that t-PA inhibitor is not concentrated into a clot and that t-PA inhibitor in plasma efficiently neutralizes t-PA incorporated in a clot.
α2-Antiplasmin depleted plasma clots were more susceptible to lysis by both endogenous and exogenous t-PA than normal clots. Removal of α2-antiplasmin from the surrounding plasma resulted in even shorter lysis times.
It is concluded that not only the concentrations of t-PA and of t-PA inhibitor play a role in the regulation of thrombolysis, but also their distribution between the clot and the surrounding plasma. In addition, α2-antiplasmin counteracts clot lysis significantly.
Answer:
C
Explanation:
because wind is generally caused my the heating of the earth surface by the sun
It could be determined that it is a living thing if it has all of the 6 characteristics of life
Answer:epidemiologists
Explanation:If a bald eagle gets mostly involved in monitoring and enforcing the protection of the bird it is a epidemiologists.