Answer:
Replication
Explanation:
Replication is the ability of an essay or experiment to be reproduced or replicated by others, in particular, by the scientific community. Replication is one of the pillars of the scientific method, with falsifiability being the other. Depending on the particular scientific field, reproducibility may require that the test or experiment be falsifiable.
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
c. decaying plant and animal remains
Answer:
The correct answer is - The amygdala
Explanation:
The amygdala is the part of the brain that is found in the medial temporal lobe of the brain. It is an almond-shaped structure of neurons. The amygdala is an essential region of the brain that has a major role in processing emotions such as aggression and others. It is the region of the limbic system that presents both sides of the brain.
Thus, the correct answer is - the amygdala.
