Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
To learn more about phenytoin click here
brainly.com/question/13386639
#SPJ4
Hello, to answer your question properly it is
C. <span>The waves emitted by the two sources have constant phase difference
Signed by, Virtuoso Sargedog
</span>
B) Detectives used DNA markers to match the pods from the truck to pods on the scene.
The most important function of osmosis is stabilising the internal environment of an organism by keeping the water and intercellular fluids levels balanced. In all living organisms, nutrients and minerals make their way to the cells because of osmosis. This obviously is essential to the survival of a cell.
