Question

Predict the effect of the E2delG mutation on the resulting FGF5-L protein. Justify your prediction. Researchers identify a different mutation in the FGF5 gene that results in the overexpression of FGF5. Predict the most likely effect of this mutation on the ratio of hairs in growth phase to hairs in rest phase compared with the ratio when the normal FGF5 allele is expressed

Answer 1

The most likely effect of FGF5 mutation is an increase on the ratio of hairs in the growth phase to hairs in rest phase compared with the ratio when the normal FGF5 allele. It leads to trichomegaly.

What does FGF5 encode?

The FGF5 gene code for glycosaminoglycan binding proteins, which are commonly expressed in the root sheath of the hair follicle.

The maximum FGF5  gene expression occurs in the late anagen step (i.e., when the hair follicle forms a new hair shaft) of the hair cycle.

Mutations of this gene (FGF5) produce trichomegaly, thereby increasing the portion of hair in the anagen phase.

Learn more about the anagen phase here:

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