Answer:
For many centuries, smallpox devastated mankind. In modern times we do not have to worry about it thanks to the remarkable work of Edward Jenner and later developments from his endeavors. With the rapid pace of vaccine development in recent decades, the historic origins of immunization are often forgotten. Unfortunately, since the attack on the World Trade Center on September 11, 2001, the threat of biological warfare and bioterrorism has reemerged. Smallpox has been identified as a possible agent of bioterrorism (1). It seems prudent to review the history of a disease known to few people in the 21st century.
Edward Jenner is well known around the world for his innovative contribution to immunization and the ultimate eradication of smallpox (2). Jenner's work is widely regarded as the foundation of immunology—despite the fact that he was neither the first to suggest that infection with cowpox conferred specific immunity to smallpox nor the first to attempt cowpox inoculation for this purpose.
Explanation:
The antibiotic called ampicillin was not effective against E.coli.
Answer: D
Explanation:
E.coli is normal microbial flora which is present in the gut of the mammals.
It is gram negative bacteria and very few strains of this bacteria causes harm.
Antibiotics are the chemical drugs which are used to treat the microbial infection either by killing the causative organism or by its growth inhibition.
Antibiotics such as neomycin, penicillin and erythromycin are usually used to treat E.coli infection.
Antibiotic such as Ampicillin is not used as the bacterium E.coli is highly resistant to it.
Answer: B (GTP serves as the energy input for AMP synthesis from IMP)
Explanation:
In the de novo synthesis of purine nucleotide, IMP represents a branch point for purine biosynthesis. IMP can be converted to either AMP or GMP.
The formation of AMP from IMP requires GTP; similarly formation of GMP requires ATP. The conversion of IMP to either AMP or GMP is highly regulated – AMP and GMP inhibits their own formation by feedback inhibition of adenlyosuccinate synthetase and IMP dehydrogenase.
