Answer:
Option A
Explanation:
During the colonial era where Europeans started settling and colonizing all over the country brought many germs with them that they were immune too. Because of that fact "New world diseases" or option A such as: chicken pox, the flu, and malaria sweeping through the country at a alarming rate killing at least 90% of Native Americans in the country.
Hope this helps.
The answer is "t<span>he confederation among the states was too strong and too centralized" as this statement is not true so it can not be a disadvantage. </span>
The west side of Europe<span />