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When the virus infects a cell, the RNA genome enters the cell and programs it to make new virus particles. These virus particles are released from the cell and go on to infect new cells. In humans, poliovirus is ingested, and replicates in cells of the gastrointestinal tract.Poliovirus, the prototypical picornavirus and causative agent of poliomyelitis, is a nonenveloped virus with a single-stranded RNA genome of positive polarity. The virion consists of an icosahedral protein shell, composed of four capsid proteins (VP1, VP2, VP3, and VP4), which encapsidates the RNA genome (1).RNA viruses generally have very high mutation rates compared to DNA viruses, because viral RNA polymerases lack the proofreading ability of DNA polymerases. The genetic diversity of RNA viruses is one reason why it is difficult to make effective vaccines against them.
What is sample size and why is it important? Sample size refers to the number of participants or observations included in a study. ... The size of a sample influences two statistical properties: 1) the precision of our estimates and 2) the power of the study to draw conclusions.
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Carbonization is the term for the conversion of an organic substance into carbon or a carbon-containing residue through pyrolysis or destructive distillation. It is often used in organic chemistry with reference to the generation of coal gas and coal tar from raw coal.