Answer:
1. d. changes in the methylation patterns of <em>loci</em> involved in growth and metabolic disease
2. b. differences in the expression of metabolic genes
d. changes in histone acetylation patterns
Explanation:
Epigenetics refers to the study of heritable changes in gene expression which are not dependent on DNA sequence. Epigenetic mechanisms involve DNA methylation, histone modifications (acetylation, methylation, phosphorylation, etc) and regulatory non-coding RNA (ncRNA) pathways. These epigenetic mechanisms work together and mutually reinforce each other in order to modulate gene expression (either by activating or suppressing gene expression). In consequence, transcriptome data (e.g., genes differentially expressed in particular tissues/cells or stages of development) is an important piece of evidence indicating the existence of epigenetic modulation.
Basically all of the choices given are failure of negative feedback mechanisms to maintain homeostasis. The correct option among all the options that are given in the question is the last option or option "E". I hope that this is the answer you were looking for and it has come to your help.
The statement 'when paired with an immunosuppressant drug, saccharine (sugar) did not have immunosuppressant effects on rats' is FALSE. Saccharine is an artificial sweetener.
<h3>Immunosuppressant drugs and saccharine</h3>
Immunosuppressant drugs are a type of drug that exhibits a depressive effect o the immune system of the individual.
Immunosuppressant drugs include, for example, adalimumab, infliximab, calcineurin inhibitors, cyclosporine, etc.
Moreover, saccharin is an artificial sweetener that is 400 times as sweet as sucrose (sugar).
Learn more about immunosuppressant drugs here:
brainly.com/question/830058