I would myself go with The use of tissue and organ transplants or the use of laser technologies to avoid open heart surgery
Prohibition would have failed regardless of the atmosphere, because people like to drink alcohol. The permisive attitude of the times (mild compared to today) meant there was little social stigma attached to those who ignored prohibition. People finally came to realize that all they did was stregnthen the mob and lose tax revenues with Prohibition.
D. is the answer became independent
The Spanish Conquistidors!
Formula : v = 4/3 π r ^3
π = 3.14159265...
V = 4/3 π (12)^3
V = 4/3 π (1728)
V = π (1728)
V = 3.14 (1728)
V = 5425.92
Hope that helps