Answer:
Multiple endocrine neoplasia external link type is a rare genetic disorder external link that mainly affects the endocrine glands external link. Located in different parts of the body, these glands control the production of hormones that direct many body processes, including
View full-sized pituitary gland, parathyroid glands, pancreas, and islets inside the pancreas
MEN1 can affect the, pancreas, and pituitary glands.
Explanation:
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Answer: .Between the ages of 4-6 years, children will,
1.) Show some awareness of moral reasoning, such as “fairness”, and good or bad behavior.
2.) Develop friendships.
Six year olds will,
1.) Understand the concept of numbers.
2. Know day from night and left from right.
3.) Be able to tell time.
Answer:
1 capsule 4 times a day.
Explanation:
Qid is a medical term meaning 4 times a day, and 1 gm= 1,000 mg.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
