One of the main characteristics of secondary granules in the neutrophilic granulocyte cytoplasm is that secondary granules will become pink/tan and will cause the basophilic color to lighten.
Promyelocytes, metamyelocytes, and myelocytes are the precursors of neutrophils, which make up the majority of the white blood cell population. The immature neutrophils are usually found only in the bone marrow.
Myeloid maturation sequence is the next stage of myelocyte. The cytoplasm of this cell starts to produce specific, secondary granules. If the cell is destined to be a neutrophil these secondary granules will be pink/tan and will further cause the basophilic color to lighten and break up. At the beginning of neutrophilia, these secondary granules are most obvious in the golgi area.
As the cell matures closer to a metamyelocyte, they fill the entire cytoplasm. While the cytoplasm shifts to producing secondary granules it also loses the prominence of its primary granules.
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