Chimericmice are generated where approximately 50% of the cells in the animal are genetically MHC class I-deficient. The other 50% are deficient for the herpes virus receptor, HVEM, but do express MHC class I molecules. When these mice are infected with herpesvirus by intraperitoneal injection, a robustvirus-specific CD8 T cell response is detected at day 7 post-infection in the spleens of the infected mice.
Chimeric mice are generated where approximately 50% of the cells in the animal are genetically MHC class I-deficient - Immunobiology
: a branch of biology concerned with the physiological reactions characteristic of the immune state
