Question

Chimeric mice are generated where approximately 50% of the cells in the animal are genetically MHC class I-deficient.

Answer 1

Chimeric mice are generated where approximately 50% of the cells in the animal are genetically MHC class I-deficient. The other 50% are deficient for the herpes virus receptor, HVEM, but do express MHC class I molecules. When these mice are infected with herpesvirus by intraperitoneal injection, a robust virus-specific CD8 T cell response is detected at day 7 post-infection in the spleens of the infected mice.

Chimeric mice are generated where approximately 50% of the cells in the animal are genetically MHC class I-deficient - Immunobiology

: a branch of biology concerned with the physiological reactions characteristic of the immune state

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