Question

The licensed practical nurse (LPN) is performing a purified protein derivative (PPD) test on a nursing home resident. Which statements about this test are correct

Answer 1

The preferred injection site is the ventral surface of the forearm and the purified protein derivative (PPD) test is an intradermal test.

Purified protein derivative

Currently, the only skin test reagent for tuberculosis diagnosis that is commercially accessible is called purified protein derivative (PPD) (TB). The purpose of this work was to create a Mycobacterium tuberculosis-specific skin test reagent that would not produce false positive findings from the Bacillus Calmette-Guerin (BCG) vaccine utilizing recombinant antigens. By comparing the proteins in the M. tuberculosis culture filtrate to the proteins in PPD IC-65 using tandem mass spectrometry, 54 proteins were discovered to be shared. Top candidates ESAT 6, CFP 10, and MPT64 were overexpressed in Escherichia coli expression strains and isolated as recombinant proteins. The antigens were tested on guinea pigs that had been exposed to M. tuberculosis H37Rv and BCG to determine the best immunodiagnostic PPD combinations to use.

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