1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
MakcuM [25]
2 years ago
12

Phenytoin blocks the opening of voltage-gated na channels in neurons. therefore, this action has its primary effects on which pa

rt of the neuron?
Biology
1 answer:
dusya [7]2 years ago
7 0

Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects.  Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.

Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.

Frequency and voltage both affect phenytoin binding.

There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.

To learn more about phenytoin click here

brainly.com/question/13386639

#SPJ4

You might be interested in
Why is meiosis described as a process of reduction division
Gnesinka [82]

Answer:

because it reduces the number of chromosomes to half the normal number so that, when fusion of sperm and egg occurs, baby will have the correct number.

Explanation:

hope this helps

plz mark brainliest

7 0
3 years ago
Do the following data come from an experiment or an observational study? A gene called ACTN3 encodes a protein which functions i
Elis [28]

Answer:

this study is clearly an observational work

Explanation:

experimental studies involve to establish direct associations between a traits and its phenotypic effects. For example, a classical experimental study would involve to map a nonsense mutation in the ACTN3 gene significantly correlated to the non-sprinting phenotype

6 0
4 years ago
Why might the cellular response to a peptide hormone be expected to be rapid compared to the cellular response to a steroid horm
topjm [15]
Peptide hormones are usually produced in the body ahead of the time when they will be required. They are usually synthesized in the inactive form and store in the secretory vesicles just under the plasma membrane. Stimulation of the signalling causes immediate release of these hormones into the surrounding medium or the blood. Thus, cellular response to a peptide hormone is always rapid compared to that of the steroid hormone.
5 0
3 years ago
According to linnaean taxonomy, what is the most specific category and level shared by humans, gorillas, and howler monkeys (fro
Mkey [24]

The most specific category and level shared by humans, gorillas, and howler monkeys (from the new world) are Suborder Anthropoidea.

<h3>What is suborder Anthropoidea?</h3>

Anthropoidea is a suborder of primates that includes humans, gorillas, and monkeys. Anthropoids are larger than prosimian primates and have flatter, more human-like faces. They also have larger brains.

Unquestionably apes, dryopithecines lived in the following Miocene. According to the conventional palaeontological theory, these Miocene apes gave rise to three new lineages in turn, one of which led to gibbons, another to big apes, and the third to humans.

However, it has long been held that the ancestors of both gibbons and orang-utans diverged from the ancestral line of the advanced Primates at an early date and that this line only later split into two groups, one of which included humans and the other of which included the gorilla and the chimpanzee; recent palaeontological evidence now tends to support this second view.

To learn more about suborder Anthropoidea, visit:

brainly.com/question/14390214

#SPJ4

5 0
1 year ago
You have a column made of nickel-agarose matrix. your protein must have ________ to use this column for affinity chromatography.
belka [17]
<span>Negatively charged R-groups in the primary structure. This is because nickel acts as a cation, therefore you would be attracting anions, in this case it would be on the proteins that would be binding to the column. Once they bind to the matrix a was buffer of high salts can elute the proteins.</span>
3 0
4 years ago
Other questions:
  • What is the name for all physical material in the universe
    10·2 answers
  • The map shows tectonic plates on Earth. The red arrows indicate which plates are converging, diverging, or transforming. Identif
    9·2 answers
  • Which of the following forces pulls water downhill until it eventually reaches the oceans?
    14·2 answers
  • One of the most basic tools of a taxonomist is a
    6·1 answer
  • What is a function of tRNA
    7·2 answers
  • Which of the following are substances intentionally put in foods to enhance appearance, palatability, safety, and/or quality? re
    8·1 answer
  • The third level of cell organization is the _____.
    8·2 answers
  • The inferior end of the adult spinal cord ends
    8·1 answer
  • Which two pancreatic hormones closely control levels of glucose in the blood
    7·1 answer
  • Which of the following is an environmental factor that leads to food insecurity?
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!