Question

A Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine With and Without Adjuvant in Healthy Older Adults

Answer 1

Respiratory syncytial virus (RSV) is an important cause of disease in older adults.

Safety and immunogenicity of a stabilized RSV prefusion F subunit (RSVpreF) vaccine candidate with/without adjuvant in adults 65 - 85 years.

What are the results of Study of a Respiratory Syncytial Virus ?

All RSVpreF vaccine candidates elicited robust and persistent serum neutralizing responses when administered alone or with SIIV.

• There was no notable difference in neutralizing response between the formulations, including those containing CpG. In the Month 0,2 Cohort, there was no booster effect of dose 2.

• SIIV responses were similar or slightly lower with concomitant administration of RSVpreF. Most systemic and local reactions were mild and more frequent after RSVpreF than placebo.

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