Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
The answer would be Active and Passive ROM
Answer:
The debates over vaccinations are often cast as arguments over the integrity of science. But they can just as easily be understood as conversations about power, writes Eula Biss, a senior lecturer at Northwestern University, in her book, On Immunity: An Inoculation. As it stands, all 50 states require specific vaccines for school-aged children, although each grants exemptions for students unable to be vaccinated for medical reasons. The power struggle—pitting parents against parents—arises in the 19 states that allow families to opt out of vaccination requirements by claiming a "philosophical exemption," whether based on personal, moral, or religious beliefs.
Explanation:
Answer:
I would explain that Dan has no symptoms because his diabetes is not in an advanced and uncontrolled state.
Explanation:
Type 2 diabetes is usually a silent disease, which does not allow people to experience any symptoms unless it is already very advanced and uncontrolled. Dan did not feel any symptoms, because the disease is still starting in his body, which facilitates treatment and control. This type of obesity develops from incorrect diet and physical inactivity, but it is possible to control it and live normally with it, mainly in cases like Dan's, which are starting.
