Question

Durairajanayagam D, Agarwal A, Ong C. Causes, effects and molecular mechanisms of testicular heat stress. Reproductive biomedicine online. 2015 Jan 1;30(1):14-27.

Answer 1

Temperature affects spermatogenesis, which functions best at body temperatures just a little lower than those.

Abstract:

To keep testicular temperatures below those of the body core, adequate thermoregulation is essential. The process of mammalian spermatogenesis and the resulting spermatozoa are negatively impacted by elevated testicular temperature. Therefore, sperm quality can be affected and the likelihood of infertility is increased by thermoregulatory dysfunction resulting in heat stress. This article reviews a variety of internal and external factors that may lead to testicular heat stress. We go into more detail on how heat stress affects the spermatogenesis process, the resulting epididymal spermatozoa, germ cells, and the alterations that result in the testis.

We also go over the chemical reactions of germ cells to heat exposure and potential processes, such as apoptosis, DNA damage, and autophagy, that could lead to heat-induced germ cell damage. Further explanation is provided for the intrinsic and extrinsic processes involved in the complex mechanism of germ cell death. These intricate apoptotic pathways ultimately result in the demise of germ cells.

Learn more about spermatogenesis here:

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