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Katena32 [7]
1 year ago
8

Patient-reported outcomes in ZUMA-7, a phase 3 study of axicabtagene ciloleucel in second-line large B-cell lymphoma

Medicine
1 answer:
EleoNora [17]1 year ago
5 0

The first comparison of PROs with axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, to SOC as second-line treatment (Tx) in relapsed/refractory (R/R) LBCL in the pivotal Phase 3 ZUMA-7 project.

According to ZUMA-7, the first randomized, international, multicenter Phase 3 study comparing axi-cel to SOC in second-line R/R LBCL, axi-cel treatment results in a clinically significant improvement in QoL at D100 when compared to SOC as determined by many recognized PRO tools. In the SOC arm, in particular, score comparisons at later timepoints call for cautious interpretation because attrition brought on by EFS events may have selected participants with the greatest results. The statistics also point to a quicker return to pretreatment quality of life with axi-cel than with SOC. Treatment options for second-line R/R LBCL should be influenced by axi-better cel's clinical results and patient experience compared to SOC.

Learn more about ZUMA-7 here:-

brainly.com/question/23849777

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The interventions would be assess the client for evidence of neuroleptic malignant syndrome, monitor vital signs to detect orthostatic hypotension, remain with the client until medication is swallowed, observe the client for acute dystonia, akathisia, and tardive dyskinesia. The correct responses are B, C, D, and E.

<h3>What is haloperidol?</h3>

Haloperidol, also known by the brand name Haldol, is a common antipsychotic medication.

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Assess the client for signs of neuroleptic malignant syndrome, monitor vital signs for orthostatic hypotension, stay with the client until medication is swallowed, and watch for acute dystonia, akathisia, and tardive dyskinesia.

Thus, the correct options are B, C, D, and E.

For more details regarding haloperidol, visit:

brainly.com/question/4489843

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Your question seems incomplete, the missing options are:

a. Monitor vital signs to detect bradycardia.

b. Remain with the client until medication is swallowed.

c. Monitor vital signs to detect orthostatic hypotension.

d. Assess the client for evidence of neuroleptic malignant syndrome.

e. Observe the client for acute dystonia, akathisia, and tardive dyskinesia.

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