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Katena32 [7]
1 year ago
8

Patient-reported outcomes in ZUMA-7, a phase 3 study of axicabtagene ciloleucel in second-line large B-cell lymphoma

Medicine
1 answer:
EleoNora [17]1 year ago
5 0

The first comparison of PROs with axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, to SOC as second-line treatment (Tx) in relapsed/refractory (R/R) LBCL in the pivotal Phase 3 ZUMA-7 project.

According to ZUMA-7, the first randomized, international, multicenter Phase 3 study comparing axi-cel to SOC in second-line R/R LBCL, axi-cel treatment results in a clinically significant improvement in QoL at D100 when compared to SOC as determined by many recognized PRO tools. In the SOC arm, in particular, score comparisons at later timepoints call for cautious interpretation because attrition brought on by EFS events may have selected participants with the greatest results. The statistics also point to a quicker return to pretreatment quality of life with axi-cel than with SOC. Treatment options for second-line R/R LBCL should be influenced by axi-better cel's clinical results and patient experience compared to SOC.

Learn more about ZUMA-7 here:-

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Excess secretion of growth hormone during early development will cause what syndrome?
erastova [34]

Answer:

Gigantism.

Explanation:

Growth hormone is also known as somatotropin. Growth hormone is a polypeptide hormone that regulates the growth, cell regeneration and cell reproduction in the organism.

The abnormal secretion of growth hormone can cause a disease. The excess secretion of growth causes gigantism during early development. The height of an individual is extremely tall than the normal individuals.

Thus, the answer is gigantism.

7 0
3 years ago
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Exercise may reduce the risk of cancer by Group of answer choices increasing appetite. increasing the levels of estrogens in the
Genrish500 [490]

Exercise may reduce the risk of cancer by encouraging the body to process and remove toxic substances.

For most healthy adults, the branch of fitness and Human offerings recommends these exercising suggestions: aerobic activity. Get at least 150 mins of moderate aerobic pastime or 75 mins of energetic cardio hobby a week, or an aggregate of slight and vigorous pastime.

Regular physical activity can enhance your muscle power and improve your endurance. exercise offers oxygen and nutrients in your tissues and allows your cardiovascular gadget paintings extra efficiently. And whilst your heart and lung health enhance, you have got greater power to address each day's chores.

A. health-associated components of physical fitness. There are 5 additives to bodily fitness:  body composition,  flexibility, muscular electricity,  muscular endurance, and cardiorespiratory patience.

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6 0
2 years ago
The physical activity health guidelines require metabolizing about _____ calories during moderate physical activity during most
Novay_Z [31]

The physical activity health guidelines require metabolizing about <u>150 to</u> <u>400</u> calories during moderate physical activity on most days of the week.

The intake of calories in the food provides the energy to do work. A very low intake of calories may result in weight loss and too much of it can make you obese. Physical activities like exercise, cycling, and jogging are necessary to burn calories.  

According to the physical activity health guidelines, adults must do moderate physical activity for at least 2hr a week. And 1 hr intense aerobic exercise a week to burn the calories.

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brainly.com/question/14338730

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7 0
1 year ago
Several studies have found that in the United States, their is a rising trend of obesity for people between the ages of 2 and 19
ale4655 [162]

I DID NOT COPY THIS. THIS IS ALL ORIGINAL: THIS TOOK 1/2 an hour to write. Hope this helps

Buried in recent headlines is the sobering fact that obesity is still on the rise in the United States. The latest federal data show that nearly 40 percent of American adults were obese in 2015–16, up from 34 percent in 2007–08. The prevalence of severe obesity also went up during the same period, from 5.7 percent to 7.7 percent. In 1985, no state had an obesity rate higher than 15 percent. In 2016, five states had rates over 35 percent.

Obesity is a grave public health threat, more serious even than the opioid epidemic. It is linked to chronic diseases including type 2 diabetes, hyperlipidemia, high blood pressure, cardiovascular disease, and cancer. Obesity accounts for 18 percent of deaths among Americans ages 40 to 85, according to a 2013 study challenging the prevailing wisdom among scientists, which had placed the rate at around 5 percent. This means obesity is comparable to cigarette smoking as a public health hazard; smoking kills one of five Americans and is the leading preventable cause of death in the United States.

The obesity crisis may be less dramatic than the opioid epidemic now gripping the nation, but it is just as deadly. Opioids accounted for around two-thirds of the 64,000 deaths related to drug overdose in 2016. Excess body weight leading to cancer causes about 7 percent of cancer-related deaths, or 40,000 deaths each year. This number doesn’t include deaths from the many other medical conditions associated with obesity. Obese people are between 1.5 to 2.5 times more likely to die of heart disease than people with normal body mass indices (BMIs).

There are also substantial economic losses associated with obesity. The medical costs of prevention, diagnosis, and treatment are estimated at $147 billion in 2008 dollars. Reduced economic productivity adds to these losses.  

Because rising obesity is attributed to an increase in caloric intake and a reduction in physical activity, many proposed solutions emphasize food and exercise. While such remedies may help in individual cases, policy solutions are almost certainly required to fight this alarming epidemic.    

Despite the thriving U.S. weight-loss market (worth $66 billion in 2017), there is no evidence that diet-related programs will curb obesity. Numerous studies indicate that diets are not effective in controlling or reversing weight gain. In fact, 50 percent of dieters weighed more than 11 pounds over their starting weight five years after their diet, according to one study.

A comprehensive discussion of the policy solutions to obesity is beyond the scope of this piece, and the jury is still out on which policies — targeting sugar consumption through taxes on sugary food and beverages, regulating nutrition labels to make them more effective in informing consumers, and limiting the advertising and marketing of unhealthy food, particularly to children — might curb the epidemic.

Taxing potentially harmful food products has shown some promise, though it is a politically fraught approach. A small number of American cities, including Philadelphia, Boulder, Colo., and Berkeley, Calif., have begun taxing sugar-sweetened beverages. Early results show that an excise tax on sugary drinks led to a 21 percent drop in their consumption in Berkeley.

Berkeley is hardly the epicenter of the obesity problem in the U.S., as the map shows, but the intervention’s success offers hope for the rest of the country. A peer-reviewed modeling study based on the Berkeley experience estimated that if a national sugar-sweetened beverages tax were implemented, it would result in lower national consumption of these drinks and reduced adult and child BMIs. Whether such a policy could be replicated nationally remains uncertain.2

When it comes to nutrition labels, there’s almost no evidence that these have an effect on consumers’ dietary intake, body weight, and overall health.  

8 0
3 years ago
What effect an atenolo 25 mg have on someone over 80
masya89 [10]

Answer: It can cause higher mortality rates, but also reduce stroke.

Explanation:

Studies show that atenolol can reduce stroke risk, but not mortality rates, heart attack rates, and cardiovascular events in the elderly.

8 0
3 years ago
Read 2 more answers
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