1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Anna71 [15]
2 years ago
11

Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis. Cell Death Differ. 2020,

Biology
1 answer:
vovangra [49]2 years ago
4 0

Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.

However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.

meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.

We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.

Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.

Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.

Learn more about breast cancer here : brainly.com/question/6747562

#SPJ4

You might be interested in
Plant and animal cells have many structures in common except for which of the following?
denis23 [38]

Answer:

A plant and animal cell both have a plasma membrane, ONLY a plant cell has a cell wall. Both of them have cytoplasm, a nucleus to guide them on what to do and ribosomes to produce protein. Only a plant contains a large vacuoles to store water and have chloroplast to do photosynthesis.

Explanation:

7 0
3 years ago
Ball-and-socket joints allow this gymnast to complete many of the routines that she performs. A gymnast is shown. In which part
Elodia [21]

The hip is a ball and socket joint.

8 0
3 years ago
I need help with questions please
aev [14]

Answer:

It is similar to skin

7 0
3 years ago
Describe how pangaea and continental drift are related
MrRa [10]
Pillow Talkin by Lil Dicky explains it all
3 0
3 years ago
Certain types of ________ have a relationship with certain plants where they help convert nitrogen into a usable form.
Viefleur [7K]

Answer:

Answer is C. Bacteria

Certain types of bacteria have a relationship with certain plants where they help convert nitrogen into a usable form.

Explanation:

Nitrogen is abundant in the atmosphere, but plants cannot use it because of the absence of a necessary enzyme, nitrogenase, which converts nitrogen into a usable form.  So they form a symbiotic relationship (mutually-beneficial arrangement) with nitrogen fixing soil bacteria (rhizobia) which perform biological nitrogen fixation. Biological nitrogen fixation is a process in which the symbiotic nitrogen-fixing bacteria coverts atmospheric nitrogen into ammonia and organic derivatives that plants can use to synthesize proteins.  This bacteria form nodules on the roots of plants like legumes in which nitrogen fixation takes place.

Both plants and bacteria benefit from this symbiotic relationship, as the plant obtains ammonia to synthesize proteins from nitrogen in the atmosphere while bacteria obtain carbon compounds from the plant produced through photosynthesis and a secure environment to grow. As the plant roots leave behind some of the usable form of nitrogen in the soil, this process also increase soil fertility.

4 0
3 years ago
Other questions:
  • A____ is a horizontal stem at or just beneath the surface of the ground which can give rise to roots or stems.
    13·2 answers
  • { Please Answer Quickly! 50 Points! }
    9·1 answer
  • The laboratory findings of an obese hypertensive adolescent reveal hyperinsulinemia and dyslipidemia. which condition is the ado
    13·1 answer
  • <img src="https://tex.z-dn.net/?f=5%284x%20%2B%203%29%20-%203%287x%20-%202%29" id="TexFormula1" title="5(4x + 3) - 3(7x - 2)" al
    13·1 answer
  • which season is occuring in Earth's northern hemisphere when Earth's southern hemisphere is tilted toward the sun?
    11·1 answer
  • In 2001, scientists announced that they had discovered a species of dinosaur called albertaceratops nesmoi that they believed to
    6·2 answers
  • The clear protein of an egg white becomes opaque and firm when cooked because the heat
    14·1 answer
  • 1. Why do atoms combine with each other? <br><br><br> 2. What determines the reactivity of an atom?
    12·1 answer
  • Help ASAP
    5·1 answer
  • Which of the following is (are) true for alleles?
    9·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!