The only way to be sure meat, poultry, or seafood is cooked long enough to kill pathogens is to cook the food at least 75 °C or hotter.
Pathogen growth is controlled by a time-temperature relationship. To kill microorganisms, food must be held at a sufficient temperature for a sufficient time.
There are many different series of continuous temperature combinations that can be equally effective.
For example, when cooking a beef roast, the microbial lethality is achieved at 121 minutes after it has reached an internal temperature of 54°C (130 F) for killing.
For most meats to kill pathogens an internal temperature should be 145 F. Poultry needs to be cooked to a slightly higher internal temperature of 165 F.
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