Question

For a given antibiotic, is there a difference in susceptibility between the gram-positive and gram-negative bacteria?

Answer 1

For a given antibiotic, is there a difference in susceptibility between the gram-positive and gram-negative bacteria due to the structure of their cell wall.

The cell wall of gram-positive bacteria consists of a single thick layer composed of peptidoglycans. On the other hand, the cell wall of gram-negative bacteria is made up of three layers.

The first layer is the outer membrane, the second layer is the peptidoglycan layer and the third layer is the inner membrane made of phospholipid bilayer.

The outer membrane of Gram-negative bacteria is the mainly responsible for resistance to a wide range of antibiotics including β-lactams and other antibiotics.

To learn more about peptidoglycan here

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