The tightness with which a chemical attaches to a binding site is termed its affinity for that site, while the effectiveness of the binding chemical is termed its efficacy.
Affinity quantifies how well a medication binds to a receptor (or how well it "fits the lock").
The ability of a drug-bound receptor to induce a response (or "turn the key") is referred to as efficacy.
While antagonists only have affinity for the receptors and no (zero) effectiveness, agonists have both affinities and efficacy for the receptor.
Effectiveness governs what transpires after the medication has been attached to the receptor through affinity.
The affinity (potency) and/or efficacy of different medicines that bind to the same receptor and elicit the same type of response will often vary from one another.
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