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Ghella [55]
2 years ago
9

Single cell transcriptomics provides insights into hypertrophic cardiomyopathy Wehrens et al. (Eva Van Rooij), 2022, Cell Report

s 39, 110809 May 10, 2022
Biology
1 answer:
Mama L [17]2 years ago
5 0

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by unexplained segmental hypertrophy, most notably in the septum. While sarcomeric gene mutations are frequently the genetic basis for HCM, the mechanistic origin of heterogeneous remodeling is still unknown.

unknown. A better understanding of the gene networks responsible for cardiomyocyte (CM) hypertrophy is required.

necessary to improve therapeutic strategies Patients with HCM frequently undergo septal myectomy surgery to relieve outflow tract obstruction caused by hypertrophy. RNA sequencing in single cells (scRNA-seq)

We discovered functional links between genes, transcription factors, and cell size in septal myectomy samples from HCM patients.

The findings demonstrate the utility of using scRNA-seq on the human hypertrophic heart, highlight CM heterogeneity, and provide a wealth of insights into molecular events involved in HCM, which can eventually lead to the development of improved therapies.

To learn more about cells from the given link

brainly.com/question/3717876

#SPJ4

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Read each description below regarding innervation of the ANS. Then click and drag each into the appropriate category base on whe
Anna35 [415]

The question is incomplete. Here is the complete question.

Read each description below regarding the dual innervation of the ANS. Then click and drag each into the appropriate category base on whether it is an example of antagonic or cooperative innervation.

The sympathetic division stimulates mucus production by salivary glands while the parasympathetic division stimulates enzyme secretion.

The sympathetic division stimulates am increase in heart rate while the parasympathetic division stimulates a decrease in heart rate.

During sex, the parasympathetic division stimulates arousal while the sympathetic division stimulates orgasm.

The parasympathetic division constricts the pupils while the sympathetic division dilates the pupils.

Antagonistic:

Cooperative:

Answer: <u>Antagonistic:</u> The sympathetic division stimulates am increase in heart rate while the parasympathetic division stimulates a decrease in heart rate; The parasympathetic division constricts the pupils while the sympathetic division dilates the pupils.

<u>Cooperative:</u> The sympathetic division stimulates mucus production by salivary glands while the parasympathetic division stimulates enzyme secretion.; During sex, the parasympathetic division stimulates arousal while the sympathetic division stimulates orgasm.

Explanation: The peripheral nervous system is divided in <u>Somatic Nervous System (SNS)</u> and <u>Autonomic Nervous System (ANS)</u>. The first is responsible for sensory input and voluntary motion.

Autonomic Nervous System is divided into <u>Sympathetic and Parasympathetic divisions</u> and is controls the fight-or-flight and rest-and-digest situations. Usually, an organ with sympathetic and parasympathetic innervations have antagonic function, such as the heart rate -  one system causes the heart rate to increase while the other stimulates the rate to decrease. However there are cases in which the combination of the 2 systems cause an increase of stimulation, producing similar effects.

Analysing each category above, it is deductable that when the sympathetic stimulates mucus production and parasympathetic, enzyme secretion and when the parasympathetic stimulates arousal and sympathetic, orgasm, in both cases, they have cooperative innervation.

On the other hand, when sympathetic stimulates increase in heart rate and parasympathetic, decrease in the rate, as stated before, and one stimulates constriction of the pupils and the other, dilation of the them, those are examples of having antagonic innervation.

5 0
3 years ago
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Ivanshal [37]
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mrs_skeptik [129]

Plants have cell walls, so cytokinesis cannot go on with a cleavage furrow, but instead, a cell plate  forms across the cell in the location of the metaphase plate.

There is no distinct groove along the cell plate as the cell divides because of the rigid nature of the cell plate or new cell wall.

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Explanation:

Protons and neutrons are subatomic particles found  in the atom of any substance.

These particles collectively determines the mass number of the atom.

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tekilochka [14]

Answer:

Model B

Explanation:

It let's more fluids flow through unlike Model A

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