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Ghella [55]
2 years ago
9

Single cell transcriptomics provides insights into hypertrophic cardiomyopathy Wehrens et al. (Eva Van Rooij), 2022, Cell Report

s 39, 110809 May 10, 2022
Biology
1 answer:
Mama L [17]2 years ago
5 0

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by unexplained segmental hypertrophy, most notably in the septum. While sarcomeric gene mutations are frequently the genetic basis for HCM, the mechanistic origin of heterogeneous remodeling is still unknown.

unknown. A better understanding of the gene networks responsible for cardiomyocyte (CM) hypertrophy is required.

necessary to improve therapeutic strategies Patients with HCM frequently undergo septal myectomy surgery to relieve outflow tract obstruction caused by hypertrophy. RNA sequencing in single cells (scRNA-seq)

We discovered functional links between genes, transcription factors, and cell size in septal myectomy samples from HCM patients.

The findings demonstrate the utility of using scRNA-seq on the human hypertrophic heart, highlight CM heterogeneity, and provide a wealth of insights into molecular events involved in HCM, which can eventually lead to the development of improved therapies.

To learn more about cells from the given link

brainly.com/question/3717876

#SPJ4

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gregori [183]

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The pedigree below tracks Duchenne Muscular Dystrophy (DMD) through several generations. DMD is an X-linked recessive trait.
Goshia [24]

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- If individual III-1 marries an unaffected, non-carrier female, none of their children will have DMD

Explanation:

From the options, the only correct statements is that  <em>If individual III-1 marries an unaffected, non-carrier female, none of their children will have DMD</em>

<u>DMD is an X-linked recessive trait, meaning that a male individual is either affected or unaffected (can never be a carrier). III-1 is unaffected and if he marries an unaffected, non-carrier female, it means that none of their children will have DMD.</u>

All the children of II-4 and II-5 will always come out with DMD because both parents are affected.

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