Question

Phosphoglucokinase catalyzes the phosphorylation of the c6-oh group of g1p. why is this enzyme important for the normal function of phosphoglucomutase?

Answer 1

Phosphoglucokinase is important as it helps in the activation of the phosphoglucomutase enzyme.

Phosphoglucokinase activity generates G1,6P, which is necessary to "prime" phosphoglucomutase that has become dephosphorylated and thereby inactivated through the loss of its G1,6P reaction intermediate.

When blood glucose levels are high, phosphoglucomutase also has the reverse effect. In this instance, phosphoglucomutase catalyzes the breakdown of glucose 6-phosphate, which hexokinase can readily produce from glucose, to glucose 1-phosphate.

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