Yes, this statement is true.
"Degradation, Foraging, and Depletion of Mucus Sialo glycans by the Vaginal-Adapted Actinobacterium Gardnerella vaginalis" Explain this study briefly.
A polymicrobial imbalance of the vaginal microbiota known as bacterial vaginosis (BV) is linked to reproductive infections, premature birth, and other detrimental health effects. Sialidase activity in vaginal secretions is a BV diagnostic marker, and sialic acid-rich mucus components have immunological and protective functions.
The role(s) of sialidases and the involvement of specific bacterial species in the breakdown of mucus barriers in BV, even though mucus degradation is thought to be significant in the etiology and problems associated with BV, have not been explored.
Here, we show that sialidase is used by the BV-associated bacterium Gardnerella vaginalis to break down and deplete sialic acid-containing vaginal mucus components.
According to biochemical data obtained from purified sialo glycan substrates, G. vaginalis extracellular sialidase hydrolyzes mucosal sialo glycans, liberated sialic acid (also known as N-acetylneuraminic acid) is transported into the bacterium, a process that is slowed down by an excess of N-glycolylneuraminic acid, and sialic acid catabolism is started by an intra G. vaginalis engaged in sialo glycan foraging in vivo in a mouse vaginal model and in vitro using human vaginal mucus, both of which resulted in sialic acid depletion.
When sialic acid levels in human vaginal specimens were analyzed, it was found that women with BV had much lower levels of sialic acid in their mucus than women with "normal" microbiotas dominated by lactobacilli.
Together, these experiments demonstrate that sialidase is used by G. vaginalis to assist the deterioration, foraging, and depletion of protective host mucus barriers. This process of mucus barrier deterioration and depletion is also seen in the clinical setting of BV.
Learn more about bacterial vaginosis (BV): brainly.com/question/14583695
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