Background- In patients with intracranial artery stenosis, a long-term advantage of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) for the prevention of recurrent stroke has not been proven. We studied patients with intracranial arterial stenosis who were enrolled in the Cilostazol Stroke Prevention Study for Antiplatelet Combination trial, a randomized controlled trial in high-risk Japanese patients with ischemic stroke, to compare the efficacy and safety of DAPT with cilostazol and clopidogrel or aspirin to those of SAPT with clopidogrel or aspirin. Techniques and Outcomes In patients with ischemic stroke with symptomatic or asymptomatic intracranial arterial stenosis of at least 50% in a major intracranial artery, we compared the vascular and hemorrhagic events between DAPT and SAPT.
Patients were divided into two groups: 275 were given DAPT, while 272 were given SAPT. In contrast to SAPT, which had a higher risk of serious or life-threatening bleeding, DAPT had a lower risk of ischemic stroke (hazard ratio [HR], 0.47; 95% CI, 0.23-0.95); and a composite of stroke, myocardial infarction, and vascular mortality (HR, 0.48; 95% CI, 0.26-0.91). Conclusions In patients with intracranial artery stenosis following stroke, DAPT using cilostazol was superior than SAPT using clopidogrel or aspirin for the prevention of recurrent stroke and vascular events without raising bleeding risk.
<h3>What is
stroke?</h3>
When anything prevents blood flow to a portion of the brain or when a blood artery in the brain bursts, a stroke, also known as a brain attack, happens. The brain either ages or suffers harm in both scenarios. A stroke may result in permanent brain damage, chronic disability, or even fatality.
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C - located in the loose connective tissue of the digestive system
For sensory information to be relayed the nerve cells should have an axon.
<u>Explanation</u>:
- Nerve cells or neurons play a critical role in transmitting signals from various sense organs of the body to the spinal cord where it is processed.
- Neurons have different parts - the dendrites which are tiny branches that receive incoming signals from the body, the nucleus, and the axon.
- The axon is a long fiber that is covered by a protective layer called myelin sheath. It is this structure of the nerve cell or neuron that helps transmit signals to the Central Nervous System of which the spinal cord is a part.
Answer:
In 1864, while working at Glasgow University as Professor of Surgery, Lister was introduced to Pasteur's germ theory of disease, and he decided to apply it to the problem of surgical infections
Extrinsic muscles are contained within a region such as the hand or the leg, and the intrinsic muscles move the fingers but are found outside the region.
