Question

A patient has an inherited defect in the liver enzyme fructose 1,6-bisphosphatase and this results in an abnormally high levels of lactate in the blood plasma. explain this observation.

Answer 1

If the live enzyme fructose 1,6- bisphosphatase defect is occured and this results in an abnormally high levels of lactate in the blood plasme this will result into the lactate will accumulate into the blood.

What is the work of fructose 1,6-biphosphatase enzyme?

In the liver, gluconeogenesis converts lactate to glucose. If FBPase-1 is defective, lactate cannot enter the gluconeogenic pathway in hepatocytes, building up in the blood.

A crucial enzyme in gluconeogenesis is fructose 1,6-bisphosphatase (FBPase). It is a possible target for drugs used to treat type II diabetes. Additionally, the protein is linked to a rare genetic metabolic disorder, and certain cancer cells lack the activity of the enzyme FBPase, which encourages glycolysis and aids in the Warburg effect.

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