Question

A polypeptide has the following amino acid sequence: Met Ser Pro Arg Leu Glu Gly For each of the following mutations, indicate the most likely type of change that occurred in the DNA (single base substitution, insertion, deletion) and the phenotypic effect of the mutation (nonsense mutation, missense mutation,frameshift mutation, etc) and whether it is a transition or transversion. Refer to a. Mutant 1: Met Ser Ser Arg Leu Glu Gly b. Mutant 2: Met Ser Pro c. Mutant 3: Met Ser Pro Asp Trp Arg Asp Lys

Answer 1

Insertion and deletion point mutations alter the reading frame from the point of mutation to the end of the gene.

What is a polypeptide?

Polypeptide: A peptide consisting of 2 or more amino acids. Amino acids make up polypeptides which, in turn, make up proteins.

Are polypeptides a protein?

Proteins are therefore also known as polypeptides.

Each type of protein has a unique sequence of amino acids, exactly the same from one molecule to the next. Many thousands of different proteins are known, each with its own particular amino acid sequence.

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