1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
babunello [35]
2 years ago
5

Papaemmanuil E, Gerstung M, Malcovati L, et al; Chronic Myeloid Disorders Working Group of the International Cancer Genome Conso

rtium. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122:3616-3627, quiz 3699.
Biology
1 answer:
Phoenix [80]2 years ago
8 0

Discussion of details on Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Clinical and biological implications of driver mutations in myelodysplastic syndromes is given in the below paragraph.

A variety of chronic hematological malignancies known as myelodysplastic syndromes (MDS) include dysplasia, inefficient hematopoiesis, and a varied risk of developing acute myeloid leukemia. Genes involved in RNA splicing, DNA modification, chromatin control, and cell signaling have been shown to have mutations thanks to the sequencing of MDS genomes. In order to investigate the impact of acquired mutations in the biology and clinical presentation of MDS, we sequenced 111 genes across 738 patients with MDS or closely similar neoplasms, such as chronic myelomonocytic leukemia and MDS-myeloproliferative neoplasms. One or more oncogenic mutations were present in 78% of individuals.

We find intricate patterns of pairwise gene linkage, suggestive of epistatic interactions involving spliceosome machinery and epigenetic modifiers. These data, when combined with inferences on subclonal mutations, point to a genetic "predestination" concept, according to which early driver mutations, generally affecting genes involved in RNA splicing, determine future disease evolution trajectories with distinct clinical manifestations. Whether clonal or subclonal, driver mutations exhibited the same prognostic relevance, and leukemia-free survival rapidly declined as the number of driver mutations rose. With a great deal of potential for clinical application, study of oncogenic mutations in sizable, well-characterized cohorts of patients therefore demonstrates the linkages between the cancer genome and disease biology.

What are Myeloid Disorders?

In myelodysplastic syndromes (MDS), a rare kind of blood cancer, there aren't enough healthy blood cells in the body.

Another name for it is myelodysplasia.

To learn more about Myeloid Disorders with the help of given link:

brainly.com/question/10373918

#SPJ4

You might be interested in
Which factors determine strength of gravitational force between two objects?
DIA [1.3K]

Answer:

mass and distance

Explanation:

As the two objects get further away, the distance between them increase and the strength of the gravitational force decreases.  If the distances decreases, the force will increase.  The bigger the object, the greater the force.

3 0
4 years ago
Read 2 more answers
Where did the carbon in living hings come
agasfer [191]
<span>It was made in stars that lived before the solar system formed.

Hope this helps!

-Payshence xoxo</span>
3 0
3 years ago
What is bacteria of decay?
IrinaVladis [17]
1. The separation of a substance into simpler substances or basic elements. 2. The process of decaying or rotting. Decomposition of dead organic matter is brought about by the activity of certain bacteria and fungi feeding on it.
6 0
4 years ago
What is the primary source of nitrogen and phosphorus for a secondary consumer? *
Feliz [49]

Answer:

Hope this helps :)

https://www.sciencedirect.com/topics/engineering/nitrogen-source

Think this is the website you're looking for

Explanation:

4 0
3 years ago
Read 2 more answers
A. Review What are the major elements of life?
tino4ka555 [31]

Answer:

1. The major elements of life are Carbon, Hydrogen, Oxygen, Nitrogen, Phosphorus and Sulfur.

2. Its ability to catenate; its ability to form bonds easily with other elements such as hydrogen, oxygen and nitrogen; its ability to form single, double and triple.

3. Carbohydrates, Proteins, Lipids, and Nucleic acids

4. Carbohydrate provide energy; Proteins serve as structural elements;

Lipids serve as structural components of membranes;

Nucleic acids store and transmit genetic information

5. Proteins are considered polymers while Lipids are not because proteins are composed of monomeric subunits of amino acids whereas lipids do not have monomeric subunits.

Explanation:

1. The major elements of life are Carbon, Hydrogen, Oxygen, Nitrogen, Phosphorus and Sulfur as they are found in many structures of living organisms- in proteins, carbohydrates, nucleic acids and lipids.

2. Carbon has the ability to form different large and complex structures because:

(I) its ability to catenate which is the ability to combine with one another to form straight, branched chain or ring compounds containing many carbon atoms.

(ii) carbon can form single, double and triple with itself and other life elements.

(iii) the relative stability of the covalent bonds formed by carbon.

3. Four groups of organic compounds found in living things are Carbohydrates, Proteins, Lipids, and Nucleic acids.

4. Carbohydrate provide energy; Proteins serve as structural elements;

Lipids serve as structural components of membranes;

Nucleic acids store and transmit genetic information

5. Polymers are large molecular weight compounds built up from subunits called monomers.

Proteins are considered polymers because they are large molecular weight molecules composed of monomeric subunits of amino acids.

Lipids are not considered polymers because individually, they are not very large molecules and do not have monomeric subunits rather are composed of long fatty acids chains linked to a glycerol molecule.

7 0
3 years ago
Other questions:
  • A 28-year-old male is admitted to the burn unit 2 hours after receiving second- and third-degree burns over 50% of his body surf
    8·1 answer
  • Match each stage of cellular respiration with the cellular location in which it occurs? cellular respiration: 1. glycolosis 3. C
    12·1 answer
  • Compare and contrast the characteristics of the ocean and ocean water
    15·2 answers
  • Is there a correlation between the number of chromosomes ad the complexity of an organism? Give support for your answer.
    12·1 answer
  • When cells are going through rapid cell divisions during the first stage of animal development called "cleavage", which of the f
    7·1 answer
  • Which of the following statements is a correct distinction between autotrophs and heterotrophs?
    9·1 answer
  • According to the basic host–pathogen model of disease, if susceptible and infected individuals are the only types of individuals
    7·1 answer
  • How did the battle between the mycenaeans and the troy begin and end?​
    5·1 answer
  • Prokaryotic cells do not contain many of the organelles that eukaryotic cells have. Prokaryotic cells do have a primitive form o
    12·1 answer
  • What region of the brain is the corpus callosum?<br><br> ОА<br> ОВ<br> Ос<br> OD
    7·2 answers
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!