Prior to therapy, a high PpIX fluorescence was observed in three patients; however, after iPDT, this fluorescence was entirely photobleached. These patients' viable tumor sections had high PpIX concentrations (mean PpIX uptake per tumor: 1.4-3.0 M).
<h3>Briefing:</h3>
However, no or just minimal PpIX uptake (0-0.6 M) could be seen in the remaining two cases. Strong PpIX uptake patients demonstrated therapeutic response and long-term clinical stabilization (no progression at 29, 30, and 36 months); the remaining two patients experienced early treatment failure (death after 3 and 9 months).
<h3>Describe fluorescence:</h3>
Two steps make up the chemical process of fluorescence first, a chemical fluorophore such a protein or carotenoid absorbs shorter-wavelength light (excitation), and then some of the absorbed energy is released as longer-wavelength light (emission).
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