For the polymerization of amino acids to form a protein, one would expect the entropy change in the reaction to be negative . this entropy change is expected because small monomers are joining to form polymer which decreases the degree of freedom.
Negative entropy change occurs when non-spontaneous change occur in the system. It means something which is more disordered will become less disordered hence energy will be required for the process.
As the monomers of the amino acids binds together to form a long polypeptide chain. It will lead to decrease in the degree of freedom of the amino acids molecule. Hence it can be called as negative entropy change.
Whenever monomers are joined together to form a macromolecule it will be show a negative entropy change.
