Cone dysfunction is a defining feature of antienolase retinopathy, a protean autoimmune retinopathy. The visual impairment and course can range from slow progression with loss of central vision to relative stability for years. Optic disc pallor can develop over time, most likely as a result of ganglion cell attrition.
Several retinal proteins, including alpha-enolase, are targeted by antibodies in paraneoplastic and autoimmune retinopathies, which are immunologically mediated retinal degenerations. In contrast to the characteristics of antirecoverin retinopathy, we present the clinical and electrophysiological features of antienolase retinopathy.
Cone dysfunction is a defining feature of antienolase retinopathy, a protean autoimmune retinopathy. The visual impairment and course can range from slow progression with loss of central vision to relative stability for years. Optic disc pallor can develop over time, most likely as a result of ganglion cell attrition.
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