Question

Mrs. sagalov has recently been diagnosed with alzheimer's disease. what clinical symptoms is she likely to show?

Answer 1

She is likely to show increasing cognitive deficits, including difficulties with memory and attention, and personality changes such as irritability, moodiness, and confusion. Her brain is likely to show senile plaques and neurofibrillary tangles, particularly in the cerebral cortex and hippocampus.

What are neurofibrillary tangles?

• Neurofibrillary tangles (NFTs), which are collections of hyperphosphorylated tau protein, are the primary biomarker for Alzheimer's disease.
• These paired helical filaments, or PHF, or hyperphosphorylated tau protein clusters.
• The specific mechanism of tangle formation is still unknown, and it is still debatable whether tangles are the primary cause of disease or only one of its many contributing elements.

• They are also present in a variety of other illnesses referred to as tauopathies.
• Their precise connection to the various diseases is unclear.
• Neurofibrillary tangles are created when the microtubule-associated protein tau is over phosphorylated to the point that it clumps together and becomes intractable.

Know more about neurofibrillary tangles with the help of the given link:

brainly.com/question/13060864

#SPJ4