The connective tissue that surrounds and separates individual skeletal muscle fibers (cells) is called epimysium.
The thick connective tissue that encircles the entire muscle tissue is called the epimysium. Typically, the epimysium is made up of several bundles (fascicles) of muscle fibers. It is a thick coating of wavy, uneven connective tissue that covers the entire muscle and shields it from contact with bones and other muscles. The endomysium and perimysium, as well as other connective tissue wrappings of the muscle, are all continuous with it. It continues with tendons as well, where it thickens and becomes collagenous. On tendons, the epimysium is regular, but it is uneven on muscles.
The layer of perimysium connective tissue separates the bundles from one another. Muscle bundles can include 50 to 300 muscle fibres per bundle, depending on their size.
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