Question

while caring for a patient with cirrhosis, the nurse knows that abnormalities in which phase of pharmacokinetics may occur?

Answer 1

Metabolism

The study of medication changes brought on by the body's physiological and metabolic processes is known as pharmacokinetics. In pharmacokinetics, there are four stages: absorption, distribution, metabolism, and excretion.

The hepatocytes are where the medication is broken down. Phase I and phase II drug metabolism occurs in the liver for the medicines. The drug's therapeutic benefits are lost during phase I metabolism as a result of oxidation, reduction, or hydrolysis.

The medication is ready to be excreted through bile or urine during phase II metabolism. Phase II of metabolism is when conjugation reactions happen. Since the liver is where medications are metabolized, a patient with liver cirrhosis will have a negative impact on drug metabolism.

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