Pyruvate enters the intermembrane space via passing through the outer mitochondrial membrane (OMM) most likely using the VDAC (IMS). The MPC then moves pyruvate throughout the IMM.
<h3>What is Pyruvate dehydrogenase ?</h3>
The reaction between pyruvate and a lipoamide, which results in acetylated dihydrolipoamide and carbon dioxide, is catalysed by the enzyme pyruvate dehydrogenase. Thiamine pyrophosphate is a coenzyme needed for the conversion.
The pyruvate dehydrogenase complex changes the chemical pyruvate, which is created when carbohydrates are broken down, into the molecule acetyl CoA. The chain of chemical events that provide energy for cells must start with this conversion.
<h3>What is Mitochondria ?</h3>
The majority of eukaryotic creatures contain a double-membrane bound organelle known as a mitochondrion. Most of the cell's adenosine triphosphate, which is used as a source of chemical energy throughout the cell, is produced by mitochondria through aerobic respiration.
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