progesterone alters gaba and glutamate responsiveness: a possible mechanism for its anxiolytic action pdf

1 answer:

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Progesterone's Neuro-modulatory properties were examined in a model extrahypothalamic CNS area's intact neuronal circuit. Before, during, and after either a systemic injection, at physiologic dosages, or local application of the steroid, the spontaneous discharge and responses of individual cerebellar Purkinje neurons to GABA and glutamate were observed. Progesterone significantly improved Purkinje cells' inhibitory responses to GABA by either method of delivery, and also inhibited glutamate excitement within 3–10 minutes after the steroid. These outcomes are in line with the steroid's anxiolytic effects.

<h3>What is Glutamate ?</h3>

The most common excitatory neurotransmitter secreted by brain nerve cells is glutamate. It is important for memory and learning. Glutamate must be present in the appropriate amounts in the right locations at the right times for your brain to work effectively.

Glutamate has more chances to continue sending messages successfully and quickly between nerve cells by connecting with four separate receptors. This quick signaling and information processing is a crucial component of memory and learning.

To know more about Glutamate please click here : brainly.com/question/17712897

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