1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
nata0808 [166]
1 year ago
5

knockout of the circadian clock protein per1 exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats

Biology
1 answer:
seropon [69]1 year ago
7 0

Knockout of the circadian clock protein per1 exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats resulting in worsening of the SS hypertensive phenotype (1).

A circadian clock factor BMAL1, significantly found in kidneys, is known to affect blood pressure. Moreover, a diet high in salt is associated with immune cell infiltration in the kidney and consequently increases blood pressure. The BMAL1 factor is also responsible for expressing various genes. Mice, when treated with BMAL1 showed aging phenotypes like muscle weakness, changed gait, decreased mobility, inactivity, etc.

PER1 is a circadian clock transcription factor and is regulated by aldosterone. Nice on PER1 knock-out develops reduced sodium excretion with day and night differences. This is done in response to a high-salt diet.

To know more about hypertension, refer to the following link:

brainly.com/question/26093747

#SPJ4

You might be interested in
In which plants' life cycle does double fertilization occur?
Otrada [13]
Double fertilization occurs in Angiosperms
5 0
3 years ago
Read 2 more answers
Which of the following is not true of a drug?
vitfil [10]

Answer:

B)t may help someone cope with life.

Explanation:

Not a long term fix

5 0
3 years ago
Anyone know how to do it or explain how to do it I’m so lost
Ainat [17]
Yes isisjdjjsjseneennsns
3 0
3 years ago
Read 2 more answers
A panda's coarse fur is made of cells, as is its blood, its skin, its nerves, and its brain. This is an example of which charact
dezoksy [38]
I believe the correct answer from the choices listed above is option D. <span>This is an example of cellular organization. Cells organize themselves according to their functions. Hope this answers the question. Have a nice day.</span>
5 0
3 years ago
Most stars end their lives as which type of star?
mestny [16]
A white dwarf is the answer
6 0
3 years ago
Other questions:
  • The formation of a cell plate is beginning across the middle of a cell and nuclei are re-forming at opposite ends of the cell. w
    7·1 answer
  • What proportion of the earth surface is grassland
    9·1 answer
  • An ecosystem contains two types of giraffes, some with short necks and others with long necks. The distribution of this trait is
    15·1 answer
  • How do the particles in plasmas compare with the particles in solids?
    8·2 answers
  • What does this difference in time suggest about the location of the two cities?
    8·1 answer
  • if a strong odour smell continuously for sometime,the sensation of smell of that substance weaken...why?
    8·2 answers
  • How much energy is passed along to each higher trophic level in a food chain?
    10·2 answers
  • What happens to the glucose molecule during the process of cellular respiration?
    10·2 answers
  • Can you pls help me??​
    14·2 answers
  • B. Absorbs water
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!