knockout of the circadian clock protein per1 exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats

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Knockout of the circadian clock protein per1 exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats resulting in worsening of the SS hypertensive phenotype (1).

A circadian clock factor BMAL1, significantly found in kidneys, is known to affect blood pressure. Moreover, a diet high in salt is associated with immune cell infiltration in the kidney and consequently increases blood pressure. The BMAL1 factor is also responsible for expressing various genes. Mice, when treated with BMAL1 showed aging phenotypes like muscle weakness, changed gait, decreased mobility, inactivity, etc.

PER1 is a circadian clock transcription factor and is regulated by aldosterone. Nice on PER1 knock-out develops reduced sodium excretion with day and night differences. This is done in response to a high-salt diet.

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