Question

The most commonly occurring mutation in people with cystic fibrosis is a deletion of a single codon. What is the result of this type of mutation? (A) a base-pair substitution
(B) a frameshift mutation (C) a polypeptide missing an amino acid (D) a nonsense mutation

Answer 1

In cystic fibrosis, the result of the deletion of a single codon is (C) a polypeptide missing an amino acid.

Cystic fibrosis is an autosomal recessive disease. It is caused due to mutation in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. There occurs a deletion of the codon encoding for phenylalanine. Its mutation is called delta F508.

Amino acids are the chemical molecules that are involved in the formation of proteins inside the living body. There are 22 types of amino acids pout of which some are essential while others are non-essential. A set of 3 mRNAs called a codon, code for an amino acid.

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