If you were to go into his brain, you may see <u>abnormal tau expression.</u>
<h3><u>What does tau exhibit itself abnormally?</u></h3>
Dysfunction results from tau's aberrant expression. Dysfunction in the mitochondria and peroxisomes is caused by tau overexpression. Oxidative stress is simultaneously exacerbated by mitochondrial dysfunction, and peroxisome dysfunction and oxidative stress itself have the capacity to exacerbate all three dysfunctions.
When tau is cleaved by proteases downstream, shortened tau is produced, which aggravates mitochondrial dysfunction even further. Tau phosphatase (PP2A) activity is decreased by oxidative stress while tau kinase (GSK-3, JNK) activity is increased.
This leads to an increase in tau phosphorylation and a reduction in tau's capacity to connect to microtubules. Tau aggregates as a result of hyperphosphorylation, which is accelerated by oxidative stress.
Learn more about abnormal tau expression with the help of the given link:
brainly.com/question/14268243
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