Distal Convoluted Tubule and Collecting Duct are parts of the nephron does ADH act on to regulate water reabsorption. ADH acts throughs G-protein coupled receptor in order to increase transcription and the insertion of Aquaporin–2 channels for the apical membrane of the CD and DCT cells. Therefore, the permeability of CD and DCT cells to the water increases.
A Distal Convoluted Tubule (DCT) is a short nephron segment, a portion of kidney nephron between Henle or macula densa and the collecting tubule loop. It plays an important role in regulating extracellular fluid volume and electrolyte homeostasis. In DCT, Sodium absorption occurs, which is mediated by the hormone aldosterone.
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